Functional NMDA Receptors in Differentiated SK-N-SH Cells

Differentiated SK-N-SH cells express functional NMDA receptors, specifically the NR1/NR2B subtype. Upon retinoic acid-induced differentiation, these cells exhibit increased sensitivity to glutamate, leading to calcium influx and acetylcholine release. This model provides a valuable system for studying NMDA receptor-mediated signaling and excitotoxicity, contributing to our understanding of neurodegenerative diseases where glutamate toxicity is implicated.